GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2275426 | 1 | rs12021587 | chr1:46472759 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs9362426 | 1 | rs1203156 | chr6:88079694 | C6orf164 | chr6:88032306-88109459:+ | -0.49 | -5.01 | 2.47E-6 | Depressive episodes in bipolar disorder |
| THYM | cis | rs6684514 | 1 | rs12041164 | chr1:156279811 | CCT3 | chr1:156278752-156308195:- | -0.18 | -4.17 | 6.84E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THYM | cis | rs2275426 | 1 | rs12049588 | chr1:46472422 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs12091564 | 1 | rs12091564 | chr1:145395604 | NOTCH2NL | chr1:145209111-145295525:+ | -0.88 | -5.72 | 1.21E-7 | Coronary heart disease |
| THYM | cis | rs7552404 | 1 | rs12091720 | chr1:76186949 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs6696239 | 1 | rs12120182 | chr1:227814332 | DUSP5P | chr1:228780657-228788159:+ | -0.81 | -5.13 | 1.51E-6 | Height |
| THYM | cis | rs7552404 | 1 | rs12123977 | chr1:76209754 | ACADM | chr1:76190043-76229353:+ | -0.36 | -4.56 | 1.53E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs7552404 | 1 | rs12126607 | chr1:76217097 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs7552404 | 1 | rs12127402 | chr1:76205643 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs6684514 | 1 | rs12132794 | chr1:156281020 | CCT3 | chr1:156278752-156308195:- | 0.18 | 4.28 | 4.4E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THYM | cis | rs2275426 | 1 | rs12139630 | chr1:46350935 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 7.1E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs12144263 | chr1:46352446 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 7.1E-8 | Body mass index |
| THYM | cis | rs1577917 | 1 | rs12154056 | chr6:86634094 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2120019 | 1 | rs12185102 | chr15:75352201 | PPCDC | chr15:75315927-75343066:+ | 0.27 | 4.81 | 5.68E-6 | Blood trace element (Zn levels) |